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Pragmatic trials are those that are designed to provide information for the practice of clinical trials in real life. They are often characterized by a focus on the practical aspects of the research design, like the recruitment and consent process in adherence, as well as the use of routinely available equipment.
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A pragmatic study that involves various investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is necessary for pragmatic trials to be able to prove their validity, and it also reduces the chance of bias in the results. However excessive heterogeneity could cause issues with the design of the trial.
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Pragmatic Play is a new player in the world of online casinos however, it has already established itself by offering mobile-friendly slots. Their games are optimized for mobile devices and run using HTML5 technology. They are also licensed and regulated by reputable gaming authorities, which ensure fairness and transparency. This is a positive indicator for players because it means the games have been tested and verified in order to guarantee the randomness and impartiality of every game.
Pragmatic Play offers not only mobile-friendly slot machines, but also table games and live casino. Pragmatic Play is licensed and regulated by a variety of regulatory bodies that include the Malta Gaming Authority and UK Gambling Commission. The games are protected by top-of-the-line encryption technology, and the company's security team is always available to assist players solve any issues they might have.
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Legality
Pragmatic Play is renowned for its top-quality games and for offering an exceptional user experience. The software is available on mobile devices and in a variety of languages. It has established itself as one of the top gaming platforms for casinos despite its relatively young age. Wolves is one of its latest releases which is a five-reel slot machine that has a high RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.
The purpose of pragmatic trials is to simulate real-life situations and achieve the highest level of validity externally. They are usually requested by practitioners and policymakers to help inform their decisions. They can be used to determine the causal relationship between an intervention and its effects. They should not, however, be used to replace explanatory studies.
The pragmatism idea is controversial, and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which prove the physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in policy and practice decision-making. They also proposed the framework for pragmatic trials, called PRECIS.2 This tool was designed to define the elements of a pragmatic trial that include recruitment, design and delivery of the intervention, and the follow-up.
The number of pragmatic trials is increasing. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. It is important to keep in mind that the majority of these trials were conducted in primary care settings.